Should you make your own hand sanitizer?
Some recipes being circulated are inaccurate and do not have a high enough alcohol percentage to be effective.
The calculator below is adapted from the World Health Organization's Guide to Local Production of WHO-recommended Handrub Formulations to contain at least 65% alcohol.
Make sure you have the following before you start:
- Materials: You will need strong enough alcohol (70% or more). Standard liquor will not work.
- Tools: You will need liquid measuring tools or a scale accurate and precise enough to measure the small quantities involved (milliliters or grams).
- Safety: Make sure you understand the safety concerns involved. You will need to label your product correctly and keep it out of reach of children.
Hand Sanitizer vs. Hand Washing
The Centers for Disease Control recommend handwashing with soap and water and using hand sanitizer when soap and water is not available.See CDC - When and How to Wash Your Hands for more information on good handwashing and sanitizer practices.


ml
(The only difference is that the recipe for hands includes glycerol / glycerin to reduce skin drying.)
Ingredient | Strength | Metric Volume | Metric Weight | Imperial |
---|---|---|---|---|
Isopropyl alcohol | ml | g | ||
Hydrogen peroxide | 3% | ml | g | |
Glycerol / glycerin | 98% | ml | g | |
Sterile cold water (distilled or boiled) |
100% | ml | g |
Total volume:
Final strength: % alcohol
Final strength: % alcohol
Tools needed
- A mixing container large enough for the total volume
- A liquid measure that can measure the amounts accurately
- A funnel
- A permanent marker and labels or tape
- Small, clean bottles (a spray top works well)
Preparation Instructions
- Carefully measure the alcohol and pour it into the mixing container.
- Carefully measure the hydrogen peroxide and pour it into the mixing container.
- Carefully measure the glycerol / glycerin and pour it into the mixing container.
- Carefully measure the sterile water. Do not exceed the amount listed. Pour it into the mixing container.
- Stir well.
- Immediately divide up the solution into its final containers (e.g. 500 ml or 100 ml plastic bottles) and place the bottles in quarantine for 72 hours before use. This allows time for any spores present in the alcohol or the new/re-used bottles to be destroyed.
Labeling
Labeling should be in accordance with national guidelines
and should include the following:
- WHO-recommended handrub formulation
- For external use only
- Avoid contact with eyes
- Keep out of the reach of children
- Date of production and batch number
- Use: Apply a palmful of alcohol-based handrub and cover all surfaces of the hands. Rub hands until dry
- Composition: ethanol or isopropanol, glycerol and hydrogen peroxide
- Flammable: keep away from flame and heat
Calculations Explained
- The recipe starts with alcohol rather than total volume, since alcohol is more likely to be in limited supply.
- Final strength: Final strength (alcohol percentage by volume) is based on WHO guidelines of 75% for isopropyl or 80% for ethanol.
- If starting with 70% or isopropyl or 75% ethanol, the final strength target is reduced to 65% to 70%, still above the 60% minimum recommended by the CDC
- Rounding: Metric calculations are rounded to milliliters or grams.
- Many households don't have more precise measurement tools.
- Small rounding differences or measurement errors will still produce an effective product, since the targets are well above the 60% minimum.
- Total volume calculation: total_volume = alcohol_volume * alcohol_percentage / final_strength
- For example, 473 (ml isopropyl) * 0.91 (91%) / 0.75 (75% strength) = 573.9, rounded to 574
- Hydrogen peroxide calculation: total_volume * 0.0417 (4.17%).
- This produces the final recommended percentage of 0.125% peroxide
- 0.0417 (4.17%) * 0.3 (3% hydrogen peroxide) = 0.001251 (0.1251%)
- Metric weight: the calculations are done in milliliters, then converted to grams based on density.
- Alcohol volume depends on temperature, so we assume 20°C / 68°F
- Total weight is based on weight of alcohol plus the weight of the remaining water
- Formula: (alcohol_volume * alcohol_percentage * density) + ( alcohol_volume * (1 - alcohol_percentage) )
- Isopropyl density: 0.7854 g/ml
- Ethanol density: 0.7892 g/ml
- Ethanol density at 32°C / 90°F is 0.77927 g/ml, so for 1000 ml of 91% alcohol, it would weigh about 9 grams less than at 20°C / 68°F, about a 1% difference which seems acceptable at this scale.
- Hydrogen peroxide weighs 1.45 g/ml. Since this uses a 3% solution (97% water) it weighs 1.0135 g/ml, close enough not to need conversion for the small amounts.
- Glycerol / glycerin weighs 1.26 g/ml.
- Water weighs 1 g/ml, so no conversion is necessary.
- Alcohol volume depends on temperature, so we assume 20°C / 68°F
Ingredient Information and FAQ
- Can I use less than 70% isopropyl alcohol in this recipe?
- No. It wouldn't be effective since the final percentage of alcohol would below the recommended 60%.
- Can I use less than 75% ethyl alcohol / 150 proof in this recipe?
- No. It wouldn't be effective since the final percentage of alcohol would be too low.
Most standard liquor such as vodka, gin, and rum is 80 to 100 proof (40% to 50% alcohol) and not suitable.
- What does the hydrogen peroxide do?
- It inactivates contaminating bacterial spores in the solution.
- From the CDC page on Chemical Disinfectants, alcohols "do not destroy bacterial spores" while "Hydrogen peroxide is active against a wide range of microorganisms, including bacteria, yeasts, fungi, viruses, and spores".
- Why does glycerol / glycerin do?
- It reduces skin drying from the alcohol which could lead to irritation and damage. Glyerin is a humectant, meaning it attracts and retains moisture.
- What about using aloe gel or other gelling agents?
- The WHO guide states, "No data are available to assess the suitability of adding gelling agents to WHO-recommended liquid formulations, but this could increase potentially both production difficulties and costs, and may compromise antimicrobial efficacy."
Additional Information
- WHO Guidelines on Hand Hygiene in Health Care
- "Alcohol solutions containing 60–80% alcohol are most effective, with higher concentrations being less potent. This paradox results from the fact that proteins
are not denatured easily in the absence of water."
- References: Larson EL, Morton HE. Alcohols. In: Block SS, ed. Disinfection, sterilization and preservation, 4th ed. Philadelphia, PA, Lea & Febiger, 1991:191–203.
- Price PB. Ethyl alcohol as a germicide. Archives of Surgery, 1939, 38:528–542.
- "Alcohols are not good cleansing agents and their use is not recommended when hands are dirty or visibly contaminated with proteinaceous materials."
- Reference: Harrington C, Walker H. The germicidal action of alcohol. Boston Medical and Surgical Journal, 1903, 148:548–552